Biography
I am currently a PhD Candidate at Spira & Lenburg lab at Boston University School of Medicine, Computational Biomedicine Section. My research interests include applying and developing computational analyses on transcriptional and post-transcriptional regulation of airway epithelium gene expression in order to facilitate the diagnosis of early lung cancer and inteception of premalignant lesion progression.
My full CV can be found at here.
Interests
- Cancer Biology
- Computational Biology
- Genomics and Epigenomics
Education
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PhD in Bioinformatics, 2017-Now
Boston University School of Medicine
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MPH in Biostatistics, 2016
Boston University School of Public Health
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BA in Molecular and Cellular Biology, 2013
Vanderbilt University
Experience & Education
Graduate Research Assistant
BUSM CBM Spira & Lenburg Lab
- Identified airway basal cell specific miRNA that contributes to bronchial PML progression using sample-match gene and miRNA expression profiles
- Led interdisciplinary investigation on Hippo and TP63 pathways as novel therapeutic targets to intercept early lung cancer progression
- Developed novel algorithm and R package
DReAmiRfor detecting miRNA regulatory network rewiring across multiple cancer-subtypes or cell-tpyes - Evaluated the predictive power of nasal epithelium miRNA expression profiles in differentiating malignant IPNs
Research Assistant
BUSPH Qiong Yang Lab
- Identified novel genetics factors and relevant pathways associated with Brain-Derived Neurotrophic Factors using genome-wide genotyping array and whole genome sequencing from FHS and other cohorts in CHARGE consortium.
- Performed GWAS collaborating with CKDGen Consortium using densely imputed FHS genotype data to identify novel loci related to kidney disease, while controlling for population substructure.
Analyst
Epidemico
- Facilitated the development of machine learning classifier for SupplyChainMap based on health informatics data
- Improved natural language processing function of SupplyChainMap, resulting in high sensitivity for differentiating true safety alert (>95%)
Research Assistant
Framingham Heart Study, Dr. Rhoda Au’s team
- Built predictive regression model for neuropsychological and MRI outcomes based on traumatic brain injury status
- Used survival analysis to analyze dementia based on Clock Drawing Test and Digital Clock Drawing Test results, and the role of APOE in the association
Research Assistant
Vanderbilt University Ellen Fanning Lab
- Identified new interaction sites between SV40 helicase and RPA 70N subunits using biochemistry and structural methods and provided evidence for its importance during viral DNA replication
Undergraduate Research Assistant
Vanderbilt University Daniel Kaplan Lab
- Identified interaction domains between Eukaryotic helicase Mcm2-7 subunits and DNA replication initiation factor Dpb11